Curated compilation of peer-reviewed research on aging biology and lifespan-extending interventions. Evidence graded by study type, effect size quantified, translational barriers documented. All claims referenced to primary literature.
Evidence-based compilation of interventions with demonstrated lifespan or healthspan effects. Each entry includes evidence level, effect magnitude, mechanism, safety profile, and primary citations.
High: Multiple randomized controlled trials (RCTs) or large prospective cohort studies (n>1,000) in humans showing consistent effects.
Moderate: Observational studies in humans or well-controlled mammalian model studies with replication.
Low: Animal model data from short-lived organisms or limited mammalian studies without human validation.
Preliminary: In vitro studies, computational predictions, or single early-stage animal studies.
Open-access literature reviews and research essays on aging biology. Content peer-reviewed via OSF Preprints with full citation lists. Focus on mechanistic understanding and evidence-based intervention assessment.
Systematic documentation of the twelve hallmarks framework (López-Otín 2023) with mechanistic details, evidence hierarchy across model organisms, human translational data, and current therapeutic approaches. 280+ primary citations.
Analysis of telomere attrition as aging hallmark: molecular mechanisms, telomerase regulation, shelterin complex function, and replicative senescence. Reviews telomere-targeted interventions including lifestyle factors and pharmacological approaches.
Comprehensive analysis of mitochondrial decline: mtDNA mutations, oxidative stress, impaired biogenesis, defective mitophagy. Reviews NAD+ restoration, mitochondrial-targeted antioxidants, exercise, and quantified effect sizes.
Examination of senescent cell accumulation, SASP secretion, and tissue dysfunction. Covers senolytic development (D+Q, fisetin, navitoclax), clinical trials, and evidence hierarchy from animal models to human translation.
To publish your OSF preprints on this site:
/publications/ folder<a href="/publications/telomeres.pdf" class="pub-link">Download PDF</a>Publication Identifiers:
VECVO is a curated research compilation focused on evidence-based longevity science. The database synthesizes peer-reviewed literature on aging biology and lifespan-extending interventions, with explicit evidence grading and citation of primary sources.
Content selection follows evidence hierarchy:
Evidence strength indicated for all claims. Translational uncertainty from model organisms to humans explicitly noted for pharmacological interventions.
Compiled by Alice Frolov, student researcher in biotechnology and longevity science (Buenos Aires, Argentina). Research focus: aging biology, cellular senescence, epigenetic reprogramming, translational barriers in longevity interventions.
Contact:
Corrections and updates welcome via GitHub with supporting citations from peer-reviewed sources.